Which clip determines the sequence settings when starting a sequence from multiple cameras?

The first clip used in a multi-camera sequence in Adobe Premiere Pro determines the sequence settings, which include aspects like frame size, aspect ratio, and frame rate. This foundational clip establishes the primary characteristics of the sequence to ensure that all clips within that sequence play harmoniously together. By guiding the sequence's overall settings, the first clip functions as a template that influences how subsequent clips are displayed and edited.

Choosing any clip, the second clip, or the last clip does not fulfill the same function; while they might indeed produce usable sequences, the parameters established by the first clip set the stage for coherent editing. Therefore, when the sequence is created, Premiere Pro prioritizes the first clip to maintain consistency throughout the edited material.