Which option in the Edit menu allows for the customization of user-defined commands?

The choice of "Key Shortcuts" from the Edit menu is indeed the correct option for customizing user-defined commands in Adobe Premiere Pro. This option provides users with the flexibility to assign, change, or create keyboard shortcuts for a wide range of commands. By accessing the Key Shortcuts dialog, users can search for specific commands and modify their associated shortcuts based on personal preferences or workflow needs. This is especially beneficial for enhancing efficiency and speeding up the editing process as it allows users to tailor the software to fit their working style.

In contrast, other options serve different purposes. "Preferences" refers to general application settings rather than specific command customizations. "Custom Layouts" focuses on the arrangement of panels within the workspace and does not pertain directly to command shortcuts. "Edit Commands" typically pertains to standard editing actions and does not provide a customizable shortcut setup, making it less relevant to the task of defining user commands. Thus, "Key Shortcuts" is the most appropriate choice for users aiming to customize how they interact with Premiere's functionalities.